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Centuries: 14th century - 15th century - 16th century
- May 10 - Amerigo Vespucci allegedly leaves Cadiz for his first voyage to the New World.
- May 13 - Pope Alexander VI excommunicates Girolamo Savonarola.
- May 20 - John Cabot sets sail from Bristol on his ship the Mathew looking for a route to the west (other documents give a May 2 date).
- June 24 - John Cabot lands in North America, either an island or the mainland.
- July 8 - Vasco da Gama begins his expedition to India.