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Centuries: 15th century - 16th century - 17th century
- May 16 - Sir Thomas More resigns as Lord Chancellor of England.
- June 25 - Suleiman I leads another invasion of Hungary, which fails miserably.
- November 16 - Francisco Pizarro and his men capture Incann Emperor Atahualpa and his nobles.
- Ataualpa wins Inca civil war over Huscar
- Spanish troops invade Peru and capture Ataualpa
- The Prince is published five years after author Niccolo Machiavelli died