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Centuries: 15th century - 16th century - 17th century
- February 12 - After claiming the throne of England the previous year, Lady Jane Grey is beheaded for treason.
- July 25 - Marriage between Queen Mary I of England and King Philip of Naples, only son of Emperor Charles V.
- August 12 - Battle of Renty. French forces led by Francis, Duke of Guise turn back an invasion of Picardy by Charles V.
- The French forces in Siena surrender to the Imperialists after a long siege