From Wikipedia, the free encyclopedia.
5-methoxy-N,N-dimethyltryptamine, (C13H18N2O), also known as 5-MeO-DMT or 5-methoxy-3-[2-(dimethylamino)ethyl]indole, is one of the most potent psychedelic entheogens known to man. It is found in a wide variety of plant species and has been used by South American shamans for over 1200 years. It was first synthesized in 1936, and in 1959 it was isolated as one of the psychoactive ingredients of Anadenanthera peregrina seeds used in cohoba snuff.
Traditionally 5-MeO-DMT was used as a psychedelic snuff or as a constituent of preparations of Ayahuasca.
When used as a drug in its purified form, 5-MeO-DMT is smoked, snorted, or injected and is active at a dose of as little as 2mg. The onset of effects occurs in seconds after smoking/injecting, or minutes after insufflating, and the experience is often described as similar to a Near Death Experience. It can also become orally active with the use of an MAOI to inhibit its quick metabolism.
Similar compounds to 5-MeO-DMT known to have psychoactive effects are DET (N,N-diethyltryptamine), DMT (N,N-dimethyltryptamine), DPT (N,N-dipropyltryptamine) and others. These produce similar yet substantially different effects than 5-MeO-DMT.
