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Drug addiction is the compulsive use of drugs despite the social, emotional, and/or physical harm they cause the individual. It is a problem which has occurred to some degree throughout recorded history (see "opium"), though modern agricultural practices and advancements in biochemistry have exacerbated the problem significantly in the twentieth century with the introduction of purified forms of active biological agents derived from plant materials, and with the synthesis of hitherto unknown substances, such as methamphetamine and gamma-hydroxybutyrate (GHB). While "addiction" has been replaced by "dependency" as a clinical term, the terms are used interchangeably here.
The addictive nature of drugs varies from substance to substance, and from individual to individual. Typically, however, drugs such as codeine or alcohol require more exposures to addict their users than drugs such as smoked heroin or crack cocaine.
The drug user is motivated to continue the use of a drug by two factors:
- the physical or psychological effect of that drug
- the need to avoid the effects of withdrawal.
The mechanisms by which drugs create physical dependence vary among drug classes.
- Depressants such as alcohol and benzodiazepines, and narcotics such as morphine and methadone, mimic endorphins and enkephalins, chemicals produced naturally by the body which produce the pleasurable sensations following sexual intercourse or exercise. These drugs are initially stimulating, but as their effects wear off, they act as a depressant.
- Stimulants such as nicotine and amphetamines act on the brain's dopamine receptors. Normally, dopamine is reabsorbed (see "reuptake") by the neurons), but stimulants block this reaction. It is this blocking which allows a crack addict, for instance, to go days without sleep.
- Alcohol
- Nicotine in the form of tobacco, particularly cigarettes
- Caffeine in the form of tea and coffee
It is unclear whether laws against drugs do anything to stem drug addiction. In jurisdictions where addictive drugs are illegal, they are generally supplied by drug dealers, who are often involved with organized crime. Even though the cost of producing most illegal addictive substances is very low, their illegality combined with the addict's need permits the seller to command a premium price, often hundreds of times the production cost. As a result, the addict must often turn to crime to support his habit.
Classes of drugs regulated by the U.S. Controlled Substances Act:
- Depressants
- Hallucinogens
- Narcotics
- Stimulants
- Anabolic steroids
- Methamphetamine and other Amphetamines
- OxyContin
- Cocaine
- LSD
- Heroin
- Ketamine
- Marijuana
- MDMA (Ecstasy)
- Steroids
- other club drugs
- Anorectic Drugs
- Barbiturates
- Benzodiazepines
- Buprenorphine
- Butorphanol
- Cannabis
- Chloral hydrate
- Codeine
- Dextroproxyphene
- Fentanyl
- Glutethimide
- Methaqualone
- Hashish
- Hashish oil
- Hydrocodone
- Hydromorphone (Dilaudid®)
- Inhalants
- Khat
- LAAM
- Meperidine
- Meprobamate
- Methadone
- Methcathinone
- Methylphenidate (Ritalin)
- Morphine
- Opium
- Pentazocine (Talwin®)
- Paraldehyde (Paral®)
- Peyote
- Mescaline
- Phencyclidine (PCP)
- Psilocybin & Psilocyn & other Tryptamines
- Rohypnol® (Flunitrazepam)
- Thebaine

