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Melchior Josef Martin Knüsel (November 16, 1813 - January 15, 1889) was a Swiss politician.
He was elected to the Federal Council of Switzerland on July 14, 1855, and handed over office on December 31, 1875. He was affiliated with the Radicals. While in office he held the following departments:
- Department of Finance (1855 - 1856)
- Department of Trade and Customs (1857)
- Department of Justice and Police (1858)
- Department of Trade and Customs (1859 - 1860)
- Political Department (1861)
- Department of Finance (1862 - 1863)
- Department of Justice and Police (1864 - 1865)
- Political Department (1866)
- Department of Justice and Police (1867 - 1873)
- Department of Home Affairs (1874 - 1875)
Predecessor: Josef Munzinger
Successor: Joachim Heer
